Watson Lees
Syracuse University
Department of Chemistry

TOP - Protein Disulfide Isomerase (PDI) catalyzes the rearrangement of improperly folded proteins by reducing their disulfides, allowing them to refold, then reforming the disulfides.

BOTTOM - The oxidized (blue) and reduced (pink) conformations of PDI are almost identical except for a single disulfide - dithiol. Small molecules might catalyze the disulfide bond rearrangement of proteins, a topic of work in our lab.